Chinese shares started lower with the blue-chip CSI300 down a shade and Hong Kong's Hang Seng index falling 0.2 per cent.
Among stocks, HCL Technologies slipped by 1.3 per cent to Rs 695.85 per share while Infosys was down by 1.1 per cent to Rs 959 per unit.
Among stocks, Hindalco emerged as the top gainer by adding 8.6 per cent at Rs 176.40 per share. Tata Steel was up by 6.6 per cent at Rs 397.05 while JSW Steel ticked up by 3 per cent to Rs 235.15 per share.
Bajaj Finance and Bajaj Finserv were up by 2.5 per cent and 2.1 per cent. The other prominent gainers were UltraTech Cement and Grasim.
Meanwhile, Asian markets rose after strong US manufacturing data and gains in tech stocks helped investors look past worries about the coronavirus and global economy.
At 10:15 am, the BSE S&P Sensex was down by 416 points or 1.11 per cent at 37,191 while the Nifty 50 slipped by 113 points or 1.02 per cent at 10,961.
However, Adani Ports, Nestle India, HCL Technologies, Infosys and Maruti Suzuki traded with a negative bias. Index heavyweight Reliance Industries was down by 1 per cent to Rs 2,155.80 per share.
However, Bharti Infratel declined by 2.2 per cent after reporting a 21 per cent drop in its consolidated net profit to Rs 704 crore for Q1 FY21.
The other prominent losers were Tata Consultancy Services, Hindalco, Coal India, Bharti Infratel and UPL. However, index heavyweight Reliance Industries advanced by 4.25 per cent to Rs 2,145.25 per share.
Bajaj Finance too slipped by 1.6 per cent after reporting 19 per cent fall in its Q1 consolidated net profit at Rs 962 crore. Larsen & Toubro, UPL and Bharat Petroleum Corporation too traded with a negative bias.